Thermo Fisher Scientific HSP701L Polyclonal Antibody
Human HSP701L 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 버퍼에 보관됩니다. 연구용으로만 사용 가능하며 안정적인 장기 보관이 가능합니다.
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Thermo Fisher Scientific HSP701L Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HSP701L. Recombinant protein control fragment (Product #RP-99553) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642572 |
Product Specific Information
Immunogen sequence:
KLYQGGCTGP ACGTGYVPGR PATGPTIEEV D
Highest antigen sequence identity to the following orthologs:
- Mouse: 81%
- Rat: 81%
Target Information
In response to adverse environmental changes, cells increase the expression of heat shock proteins.
The small heat shock proteins group includes diverse proteins ranging from ~15 to >30 kDa.
A relationship between elevated stress protein expression and neoplasia has been observed, particularly in estrogen-induced proteins in breast cancer cells.
Hsp27 shows rapid phosphorylation in response to mitogens, tumor promoters, and calcium ionophores.
The 24 kDa estrogen-induced protein correlates with steroid hormone receptor expression and is highly expressed in breast carcinoma.
Studies suggest that Hsp27 levels also correlate with endometrial adenocarcinomas.
Regulation of human Hsp27 by estrogens and heat shock resembles ecdysteroid and heat shock activation of drosophila Hsp20 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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