Thermo Fisher Scientific Ets-1 Polyclonal Antibody
Ets-1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IP에 적합합니다. 인간 반응성으로 Mouse, Rat, Chicken 등에도 예측 반응합니다. 1 mg/mL 농도의 액상 형태이며 항원 친화 크로마토그래피로 정제되었습니다.
- 카탈로그번호
- A303500A
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Ets-1 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 and 225 of human v-ets Erythroblastosis Virus E26 Oncogene Homolog 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, X. laevis, and Chicken
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); ETS-1; EWSR2; p54) is a 441 amino acid DNA-binding protein belonging to the ETS family.
It includes:
- N-terminal pointed domain
- Central transactivation domain
- Two auto-inhibitory domains flanked by conserved C-terminal Ets domain
ETS1 interacts with factors such as PEBP2alphaA and p300/CBP, mediating transactivation of Osteopontin, Presenilin-1, Stromelysin, and Collagenase.
It is activated by Ras/MAPK signaling and up-regulated in resting T-cells.
Activity modulation involves AP-1, Sp-1, c-myb, and MafB.
Sp100 activates ETS1 in nuclear bodies.
ETS1 interacts with EAP1/Daxx to repress MMP1 and BCL2 transactivation, and with STAT6 to modulate Socs-1 expression induced by IL-4.
It also interacts with GATA3 to positively regulate Tax-1 dependent IL-5 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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