Thermo Fisher Scientific PDI Polyclonal Antibody
Thermo Fisher Scientific의 PDI Polyclonal Antibody는 Human, Mouse, Rat 시료에 반응하며 Western blot, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 Rabbit IgG 항체로, 세포 내 단백질의 이황화 결합 형성 및 재배열 연구에 활용됩니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PDI Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human P4HB. Recombinant protein control fragment (Product #RP-100458). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789796 |
Product Specific Information
Immunogen sequence:
LPLVIEFTEQ TAPKIFGGEI KTHILLFLPK SVSDYDGKLS NFKTAAESFK GKILFIFIDS DHTDNQRILE FFGLKKEECP AVRLITLEEE MTKYKPESEE LTAERITEFC HRFLEGKIKP HLMSQELPED WDKQPVKVLV GKNF
Target Information
Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage, and rearrangement of disulfide bonds.
At the cell surface, PDI acts as a reductase that cleaves disulfide bonds of proteins attached to the cell, potentially causing structural modifications of exofacial proteins.
Inside the cell, it facilitates disulfide bond formation and rearrangement in nascent proteins.
At high concentrations, PDI functions as a chaperone preventing aggregation of misfolded proteins, while at low concentrations, it can promote aggregation (anti-chaperone activity).
PDI may also participate with other chaperones in structural modification of the TG precursor in hormone biogenesis and serves as a structural subunit of enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein (MTTP).
It also acts as a receptor for LGALS9, retaining P4HB at the cell surface of Th2 T helper cells, which enhances disulfide reductase activity and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.