Thermo Fisher Scientific PGR Monoclonal Antibody (OTI4A11), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The progesterone receptor (PR) is a member of the steroid nuclear receptor family and mediates the physiological effects of progesterone, a key hormone in reproductive processes such as pregnancy establishment and maintenance.
PR exists as two isoforms: a 94 kDa form (A) and a 120 kDa form (B), resulting from alternative translation initiation sites. PR-B is transcriptionally active, regulating genes for endometrial maintenance, pregnancy, and ovulation inhibition.
PR-A differs by a 165 amino acid deletion at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
Inactive PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational change, dimerizes, and binds progesterone response elements (PRE), leading to transcriptional activation.
Mutations in the PGR gene can cause reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.