Thermo Fisher Scientific FOLR4 Monoclonal Antibody (12A5)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1:10-1:1,000

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

12A5

Immunogen

CD3 mAb-stimulated CD4/CD25 T cells. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FOLR4,uniProtId:Q9EQF4-1,ncbiNodeId:10090,antigenRange:1-244,antigenLength:244,antigenImageFileName:MA5-24803_FOLR4_Q9EQF4-1_Rat.svg,antigenImageFileNamePDP:MA5-24803_FOLR4_Q9EQF4-1_Rat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2717276

Target Information

FR4 is a heavily glycosylated 35 kD receptor for folic acid and the physiologic circulating form of the vitamin, N5-methyltetrahydrofolate. Natural T regs have high levels of FR4 and together with CD25 can be used to distinguish natural Tregs, effector T cells, memory-like T cells and naive T cells. In vivo studies with eBioTH6 show a decrease in the number of CD4+CD25+ cells and an enhanced tumor response leading to the elimination of advanced stages of tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.