Thermo Fisher Scientific CTDSPL Monoclonal Antibody (6F9C5)
CTDSPL 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF, Flow Cytometry, ELISA 등 다양한 연구용 응용에 적합합니다. 1 mg/mL 농도의 액상 형태이며, Protein G로 정제되어 안정적인 결과를 제공합니다.
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Thermo Fisher Scientific CTDSPL Monoclonal Antibody (6F9C5)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6F9C5 |
| Immunogen | Partial recombinant human CTDSPL (residues 1–200) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.5% proprietary stabilizer |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2717271 |
Target Information
CTDSPL is recruited by REST to neuronal genes containing RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. It preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7-residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. This activity negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
(Source: UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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