Thermo Fisher Scientific POLE3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, POLE3 shRNA-transfected 293T
• Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (81%), Xenopus laevis (90%), Chicken (90%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family and exists as two isoenzymes: sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes.
Mitochondrial creatine kinase occurs in two oligomeric forms (dimers and octamers), whereas cytosolic creatine kinase isoenzymes are exclusively dimeric. Sarcomeric mitochondrial creatine kinase shares 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase.
This gene contains sequences homologous to motifs shared among nuclear genes encoding mitochondrial proteins and may be essential for coordinated activation during mitochondrial biogenesis. Three transcript variants encoding the same protein have been identified.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.