Thermo Fisher Scientific ALKBH1 Monoclonal Antibody (OTI1B8), TrueMAB
인간 ALKBH1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, IHC(P)에서 1:150 희석으로 검증됨. 무보존제, 동결건조 형태이며 PBS/trehalose 버퍼에 보관. DNA 손상 복구 연구용으로 적합하며 carrier-free 형태로 접합 실험에도 사용 가능.
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Thermo Fisher Scientific ALKBH1 Monoclonal Antibody (OTI1B8), TrueMAB
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–245 of human ALKBH1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
This gene encodes a homolog to the E. coli alkB gene product, which participates in the adaptive response mechanism for DNA alkylation damage repair.
It functions through oxidative demethylation of 1-methyladenine and 3-methylcytosine, repairing alkylated single-stranded DNA and RNA.
Requires molecular oxygen, alpha-ketoglutarate, and iron for activity.
May play a role in placental trophoblast lineage differentiation and exhibits DNA lyase activity, introducing double-stranded breaks at abasic sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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