Thermo Fisher Scientific RB1 Monoclonal Antibody (OTI3F11), TrueMAB
RB1 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. Human 시료에 반응하며, 고순도 친화 크로마토그래피 정제 항체입니다. PBS/BSA/glycerol buffer에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 309–590 of human RB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine residues, but not on tyrosine. It forms complexes with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription, and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in various cancers including breast, colon, prostate, kidney, nasopharyngeal carcinoma, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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