Thermo Fisher Scientific PPP6C Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human PPP6C. Recombinant protein control fragment (Product #RP-101223). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PPP6C,uniProtId:O00743-1,ncbiNodeId:9606,antigenRange:262-305,antigenLength:305,antigenImageFileName:PA5-84040_PPP6C_O00743-1_Rabbit.svg,antigenImageFileNamePDP:PA5-84040_PPP6C_O00743-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2791192

Product Specific Information

Immunogen sequence: CYRCGNIASI MVFKDVNTRE PKLFRAVPDS ERVIPPRTTT PYFL

Target Information

Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5to 3 exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5and 3 overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5and 3 overhang processing in nonhomologous DNA end joining.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.