Thermo Fisher Scientific MPZ Monoclonal Antibody (C13)

Applications

• Western Blot (WB): 0.002–2 µg/mL

Product Specifications

Target Information

Zero, also known as myelin protein zero (MPZ), is a Type I integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath to ensure stable synaptic transmission. MPZ constitutes approximately 50% of total protein in the sheath scaffolding, contributing to the structural integrity of peripheral myelin. It guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g., G134R) can disrupt multimer formation, cause demyelinating neuropathies, and contribute to conditions such as Charcot-Marie-Tooth disease. The cytoplasmic domain undergoes serine and tyrosine phosphorylation, prevalent during peak nerve myelination. MPZ transcript is moderate in brain, abundant in thymus, and most abundant in white matter of the CNS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.