Thermo Fisher Scientific OST-beta Polyclonal Antibody
OST-beta 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ELISA 등에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도. 연구용으로 bile acid 수송 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| ELISA | 1:500–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human OST-beta (amino acids 1–35) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney, and adrenal gland.
OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This regulation allows bile acids to modulate their own efflux rate from enterocytes.
OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha for plasma membrane localization. Coexpression of OST Alpha and OST Beta promotes glycosylation and trafficking of OST Alpha through the Golgi apparatus.
Though widely expressed, OST Beta shows highest expression in the ileum.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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