Thermo Fisher Scientific Viperin Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 118-361 of human RSAD2 (NP_5423882) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Viperin,uniProtId:Q8WXG1-1,ncbiNodeId:9606,antigenRange:118-361,antigenLength:361,antigenImageFileName:PA5-117125_Viperin_Q8WXG1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-117125_Viperin_Q8WXG1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.61 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2901755

Product Specific Information

Positive Samples: PC-3, Mouse spleen, Rat lung, Rat spleen, Rat kidney

Immunogen sequence: EKINFSGGEP FLQDRGEYLG KLVRFCKVEL RLPSVSIVSN GSLIRERWFQ NYGEYLDILA ISCDSFDEEV NVLIGRGQGK KNHVENLQKL RRWCRDYRVA FKINSVINRF NVEEDMTEQI KALNPVRWKV FQCLLIEGEN CGEDALREAE RFVIGDEEFE RFLERHKEVS CLVPESNQKM KDSYLILDEY MRFLNCRKGR KDPSKSILDV GVEEAIKFSG FDEKMFLKRG GKYIWSKADL KLDW

Target Information

Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.