Thermo Fisher Scientific TACR3 Polyclonal Antibody
TACR3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P) 적용 가능. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from N-terminal extracellular domain of human TACR3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551600 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla (100%); Gibbon, Monkey (95%).
Target Information
The tachykinins are a family of small peptides including neurotransmitters substance P, neurokinin A, and neurokinin B, which act on three related but distinct seven transmembrane G-protein coupled receptors.
The NK-3 receptor (NK3R) shows the greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Upon ligand binding, NK3R activates a phosphatidylinositol-calcium second messenger system, likely leading to the release of vasopressin and oxytocin.
NK3R may be involved in learning and memory, as mice lacking this gene exhibit cognitive deficits. It may also play a role in regulating vagal afferent relay neurons, although activation in airway nerves is likely mediated by substance P or neurokinin A rather than neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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