Thermo Fisher Scientific GPR112 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
INTGKSQWEK PKFKQCKLLQ ELPDKIVDLA NITISDENAE DVAEHILNLI NESPALGKEE TKIIVSKISD ISQCDEISMN LTHVMLQIIN VVLEKQ

Antigen sequence identity:

• Mouse: 79%
• Rat: 27%

Target Information

G protein-coupled receptors (GPRs or GPCRs), also known as seven transmembrane receptors or 7TM receptors, are members of the largest protein family involved in various stimulus-response pathways. They mediate extracellular signals into intracellular responses through G protein activation and respond to signaling molecules such as hormones, neurotransmitters, and peptides.

GPR112 (G protein-coupled receptor 112) is a 3,080 amino acid multi-pass membrane protein belonging to the G-protein coupled receptor 2 family and LN-TM7 subfamily. Localized to the cell membrane, GPR112 is highly expressed in normal enterochromaffin cells, as well as in neuroendocrine and primary liver carcinoma. It contains one GPS domain and may function as an orphan receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.