Thermo Fisher Scientific MXI1 Polyclonal Antibody
Rabbit polyclonal antibody against human MXI1 for IHC(P) applications. Recognizes recombinant human MXI1 protein with high species conservation. Purified by antigen affinity chromatography and supplied in PBS with glycerol. For research use only.
- 카탈로그번호
- PA557225
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MXI1. Recombinant protein control fragment (Product #RP-95284) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644322 |
Product Specific Information
- Immunogen sequence: HTTLGLLNKA KAHIKKLEEA ERKSQHQLEN LEREQRFLKW RLEQLQGPQE MERIRM
- Sequence identity: Mouse – 98%, Rat – 98%
Target Information
Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. Max is an obligate heterodimeric partner for Myc and also forms heterodimers with proteins such as Mad1, Mxi1, Mad3, and Mad4. Association of Mad3 and Mad4 with Max results in transcriptional repression. Both Myc and Mad proteins have short half-lives and tightly regulated synthesis, while Max expression is constitutive and stable.
Two mammalian cDNAs encode Mad-binding proteins, mSin3A and mSin3B, which share sequence homology with the yeast transcription repressor Sin3, including four conserved PAH domains. These interact with Mad proteins via PAH2, suggesting that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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