Thermo Fisher Scientific Phospho-Syk (Ser297) Polyclonal Antibody
인간 SYK 단백질의 Ser297 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P)에서 사용 가능. 비결합형 액상 형태로 1 mg/mL 농도. PBS/glycerol buffer에 보관하며, -20°C에서 저장.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SYK (Accession P43405), corresponding to amino acid residues around phosphorylated Ser297. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816136 |
Product Specific Information
This antibody detects endogenous levels of SYK only when phosphorylated at Ser297.
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases considered potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) activation, Syk translocates to the plasma membrane and phosphorylates downstream adaptor proteins, initiating signaling pathways related to calcium mobilization, cytoskeleton remodeling, and gene transcription. Syk binds to receptor assemblies through SH2 domain interactions with ITAM motifs phosphorylated by Src-family kinases, which also activate Syk via phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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