Thermo Fisher Scientific PSD93 Polyclonal Antibody
PSD93 단백질을 인식하는 Thermo Fisher Scientific의 고품질 Rabbit Polyclonal Antibody. WB, IHC, ICC 등 다양한 응용 가능. Mouse 및 Rat에서 반응. 고순도 항원 친화 크로마토그래피 정제. 연구용 전용 제품.
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Thermo Fisher Scientific PSD93 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of mouse PSD93 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2792916 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%).
- Positive Control: mouse brain, rat brain.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PSD-93, also known as chapsyn-110, is a plasma membrane-associated protein found in synaptic junctions. It is uniquely expressed in Purkinje neuron cell bodies and dendrites. PSD-93 contains three PDZ domains (~90 amino acids each), one SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive.
PDZ-domain interactions are believed to play a role in receptor and channel clustering contributing to neuronal plasticity. PSD-93 participates in clustering of NMDA receptors and shaker-type potassium channels at the synaptic membrane.
These proteins share a C-terminal sequence motif (T/SXV), which mediates PDZ-domain binding. Neuronal nitric oxide synthase (nNOS), lacking this motif but containing its own PDZ domain, can interact with PSD-93 via a pseudo-homotypic PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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