Thermo Fisher Scientific PALB2 Polyclonal Antibody
PALB2 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간에 반응하며 IHC 및 IHC(Paraffin) 실험에 적합. 액상 형태로 항원 친화 크로마토그래피로 정제됨. DNA 손상 복구 관련 BRCA 단백질 연구에 유용.
- 카탈로그번호
- IHC00251x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PALB2 Polyclonal Antibody
Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 200 and 250 of human partner and localizer of BRCA2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Crab-eating macaque
Target Information
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer.
PALB2 is required for the localization of BRCA2 to sites of DNA damage and, like BRCA1 and BRCA2, is a breast cancer susceptibility gene. It functions by binding directly to BRCA1, organizing BRCA2 and the recombinase RAD51 at DNA damage sites.
Analysis of the BRCA1–PALB2–BRCA2–RAD51 network may help predict tumor responsiveness to therapeutic treatments.
At least four isoforms of PALB2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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