Thermo Fisher Scientific ACAT2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
LVSTRKGLIE VKTDEFPRHG SNIEAMSKLK PYFLTDGTGT VTPANASGIN DGAAAVVLMK KSEADKRGLT

Target Information

This gene represents a member of the frizzled gene family, which encodes 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The encoded protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains. Unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. It functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, inhibiting oncogenic transformation, cell proliferation, and apoptosis inhibition. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.