Thermo Fisher Scientific FBLIM1 Polyclonal Antibody
Rabbit polyclonal antibody against human FBLIM1 protein. Validated for WB and IHC applications. High specificity and affinity via antigen affinity purification. Supplied as liquid form with PBS buffer and glycerol for stable storage.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FBLIM1 (Product #RP-88641) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641522 |
Product Specific Information
Immunogen sequence:
CEPCYQDTLE RCGKCGEVVR DHIIRALGQA FHPSCFTCVT CARCIGDESF ALGSQNEVYC LDDFYRKFAP VCSICENPII PRDGKDAFKI ECMGRNFHEN CYRCEDCRIL LSVEPTDQGC YPLNNHLFCK PCHV
Highest antigen sequence identity to the following orthologs:
- Mouse: 89%
- Rat: 88%
Target Information
The FBLIM1 gene encodes a protein with:
- An N-terminal filamin-binding domain
- A central proline-rich domain
- Multiple C-terminal LIM domains
This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. It is involved in actin-filament assembly and stabilization, modulating cell adhesion, morphology, and motility.
Additionally, FBLIM1 localizes to the nucleus and may affect cardiomyocyte differentiation through interaction with the CSX/NKX2-5 transcription factor.
Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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