Thermo Fisher Scientific APP Monoclonal Antibody (OTI6F11), Biotin, TrueMAB
인간 APP 단백질을 인식하는 단클론 항체로, Biotin으로 표지된 TrueMAB 형식입니다. Luminex 분석에 적합하며, 고순도의 Affinity chromatography 정제 제품입니다. 알츠하이머병 연구 등 APP 관련 연구에 활용 가능합니다.
- 판매단위
- pk
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Applications
- Luminex (LUM): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6F11 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cell |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating the axonal transport of beta-secretase and presenilin 1. APP plays a key role in neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with multiple isoforms due to alternative splicing. Proteolytic cleavage by beta- and gamma-secretases generates beta amyloid, the major component of senile plaques—one of the hallmark features of Alzheimer’s disease. Abnormal APP regulation and processing are also implicated in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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