Thermo Fisher Scientific APP Monoclonal Antibody (OTI7B8), Biotin, TrueMAB
인간 APP 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로 Biotin 결합형입니다. Luminex 분석에 적합하며, 고순도의 친화 크로마토그래피로 정제되었습니다. 알츠하이머 및 신경 관련 연구용으로 사용됩니다.
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- TA700259
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Thermo Fisher Scientific APP Monoclonal Antibody (OTI7B8), Biotin, TrueMAB
Applications
- Luminex (LUM)
Tested Dilution
- Assay-dependent
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B8 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cell |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1. APP is crucial for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with multiple isoforms from alternative splicing. Proteolytic cleavage by beta- and gamma-secretases generates beta amyloid, the main component of senile plaques, a hallmark of Alzheimer’s disease. Abnormal APP regulation is associated with Down’s syndrome, familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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