Thermo Fisher Scientific Phospho-Desmin (Thr17) Polyclonal Antibody
Phospho-Desmin (Thr17) 폴리클로날 항체로 Western blot 및 ELISA에 적합. 사람, 마우스, 랫트 시료에 반응하며 Rabbit IgG 유래. Protein A로 정제된 액상 항체로, -20°C에서 보관. 근육세포 특이적 단백질 Desmin의 인산화 상태 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human DES around the phosphorylation site of Thr17 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Desmin (approximately 53 kDa) exhibits high tissue specificity, predominantly expressed in all types of muscle cells including cardiac, skeletal, and smooth muscle. Its expression is stage- and tissue-specific, being induced during terminal development such as skeletal muscle differentiation. In skeletal and cardiac muscle cells, desmin is localized in the Z-disk region and at the intercalated disk. Expression in smooth muscle is more heterogeneous. Coexpression of vimentin and desmin has been observed in muscle-derived tumors such as rhabdomyosarcomas and leiomyosarcomas. During myocardial dysfunction, dramatic changes in desmin distribution have also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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