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Thermo Fisher Scientific Phospho-DDX58 (Ser8) Polyclonal Antibody
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Human RIG-I 단백질의 Ser8 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Protein A 정제, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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마지막 업데이트 2025. 08. 04. 오전 06:33
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Thermo Fisher Scientific BS-5299R Phospho-DDX58 (Ser8) Polyclonal Antibody 100 ul pk판매 단위 pk ·
재고 확인 필요
569,000원VAT 포함 625,900원
Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-DDX58 (Ser8) Polyclonal Antibody
Thermo Fisher Scientific Phospho-DDX58 (Ser8) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human DDX58 around the phosphorylation site of Ser8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor (PRR) involved in the detection of viral double-stranded RNA (dsRNA). Along with MDA5, RIG-I activates innate immune responses by recognizing viral RNA.
- RIG-I detects short dsRNAs and those lacking a 5'-triphosphate end.
- MDA5 detects long dsRNAs.
Once activated, both signal through IPS-1 to activate NF-κB and IRF-3, leading to apoptosis, cytokine signaling, and inflammation.
RIG-I is essential for responses to influenza A/B, respiratory syncytial virus, paramyxoviruses, Japanese encephalitis virus, and West Nile virus.
MicroRNA-146a negatively regulates RIG-I-dependent antiviral responses by targeting TRAF6, IRAK1, and IRAK2.
Recent studies suggest RIG-I also detects cytosolic DNA via RNA polymerase III activity.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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