ELK Biotechnology COX2/Cyclooxygenase 2 Mouse mAb
COX2/Cyclooxygenase 2 Mouse 단클론 항체로 인간, 랫, 마우스 시료에 반응합니다. IHC에 적합하며 1:100–200 희석 권장. 합성 펩타이드 면역원 기반으로 제작되었으며, -20°C에서 안정적으로 보관 가능합니다. 염증성 사이클로옥시게나제 연구에 활용됩니다.
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COX2/Cyclooxygenase 2 Mouse mAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | COX2/Cyclooxygenase 2 Mouse mAb |
| Reactivity | Human, Rat, Mouse |
| Alternative Names | PTGS2 antibody, Prostaglandin H2 synthase 2 antibody, PGHS 2 antibody, Glucocorticoid-regulated inflammatory cyclooxygenase antibody |
| Source | Mouse |
| Applications | IHC |
| Species | Human |
| Recommended dilutions | IHC 1:100–200 |
| Immunogen | Synthetic Peptide |
| Storage | PBS with 0.02% sodium azide and 50% glycerol (pH 7.4). Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1 mg/ml |
| Observed band | 70 kDa |
| GeneID (Human) | 5743 |
| Human Swiss-Prot No | P35354 |
| Cellular localization | Endoplasmic reticulum, Membrane, Microsome |
Background
Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 (COX-2), is an enzyme encoded by the PTGS2 gene in humans.
There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 and an inducible COX-2, differing in their regulation and tissue distribution.
Expression of these transcripts is regulated by cytokines and growth factors.
A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs but is non-functional in humans.
Two smaller COX-1-derived proteins (PCOX-1A and PCOX-1B) have also been discovered, though their roles remain unclear.
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