ELK Biotechnology β-Catenin Mouse mAb
β-Catenin 단백질을 인식하는 Mouse 단클론 항체. Human, Rat, Mouse에 반응하며 WB, IHC에 적합. 세포 접합부 및 세포막 등에서 발현되는 β-Catenin 검출에 사용. 안정한 PBS/glycerol buffer에 보관 가능.
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제품명
β-Catenin Mouse Monoclonal Antibody
제품 개요
이 항체는 β-Catenin 단백질을 특이적으로 인식하는 마우스 유래 단클론 항체입니다. 다양한 종(Human, Rat, Mouse)에 반응하며, Western Blot(WB) 및 Immunohistochemistry(IHC) 실험에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | β-Catenin Mouse mAb |
| Reactivity | Human, Rat, Mouse |
| Alternative Names | b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286 |
| Source | Mouse |
| Applications | WB, IHC |
| Species | Human |
| Recommended Dilutions | WB 1:1,000–2,000 / IHC 1:200–500 |
| Immunogen | Recombinant Protein |
| Storage | PBS with 0.02% sodium azide and 50% glycerol (pH 7.4). Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1 mg/ml |
| Observed Band | 92 kDa |
| Gene ID (Human) | 1499 |
| Human Swiss-Prot No | P35222 |
| Cellular Localization | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus, Synapse |
Background
The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by the Wnt1 proto-oncogene. The central core region of beta-catenin is involved in mediating cadherin–catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.
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