ELK Biotechnology PDGFRα (5D1) Mouse mAb
PDGFRα 단백질을 인식하는 Mouse 단일클론 항체로, Human, Mouse, Rat 시료에 반응합니다. IHC 실험에 적합하며, 세포막에 위치한 PDGFRα를 검출합니다. 합성 펩타이드로부터 제작되었으며, 안정적인 PBS/glycerol 용액에 보관됩니다.
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PDGFRα (5D1) Mouse Monoclonal Antibody
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PDGFRα (5D1) Mouse mAb |
| Reactivity | Human, Mouse, Rat |
| Alternative Names | N/A |
| Source | Mouse |
| Applications | IHC |
| Species | Human |
| Recommended dilutions | IHC 1:100–200 |
| Immunogen | Synthetic Peptide |
| Storage | PBS with 0.02% sodium azide and 50% glycerol (pH 7.4). Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1 mg/ml |
| Observed band | 180 kDa |
| GeneID (Human) | 5156 |
| Human Swiss-Prot No | P16234 |
| Cellular localization | Membrane |
Background
Platelet derived growth factor (PDGF) family proteins exist as several disulfide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC, and PDGF DD) that bind specifically to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ).
PDGFRα and PDGFRβ can each form heterodimers with EGFR, which is also activated by PDGF. Various cells differ in receptor number and subunit composition, accounting for differences in PDGF responsiveness.
Ligand binding induces receptor dimerization and autophosphorylation, followed by activation of cytoplasmic SH2 domain-containing signaling molecules such as GRB2, Src, GAP, PI3 kinase, PLCγ, and NCK. These pathways regulate cell growth, actin reorganization, migration, and differentiation.
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