ELK Biotechnology SH21A rabbit pAb
SH21A rabbit polyclonal antibody는 인간, 마우스, 랫트에 반응하며 WB 및 ELISA에 사용됩니다. SH2 도메인을 포함한 단백질을 인식하여 T 및 B 세포 자극에 관여합니다. 고순도 IgG 형식으로 제공되며 -20°C에서 1년 보관 가능합니다.
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제품명
SH21A rabbit pAb
적용 분야
- Western Blot (WB)
- ELISA
권장 희석 배율
- WB: 1:500–1:2000
- ELISA: 1:5000–1:20000
제품 정보
| 항목 | 내용 |
|---|---|
| Immunogen | Synthesized peptide derived from part region of human protein |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 14 kD |
| GeneID (Human) | 4068 |
| Human Swiss-Prot No | O60880 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human, Mouse, Rat |
| Storage | -20°C / 1 year |
배경 (Background)
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found.
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