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ELK Biotechnology SRPK2 rabbit pAb
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SRPK2 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인산화 조절 및 스플라이싱 관련 연구에 활용되며, 인간 및 생쥐 시료에 반응합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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- pk
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ELK Biotechnology ES10216-100UL SRPK2 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES10216-50UL SRPK2 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology SRPK2 rabbit pAb
SRPK2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | SRPK2 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 75 kD |
| GeneID (Human) | 6733 |
| Human Swiss-Prot No | P78362 |
| Cellular Localization | Cytoplasm, Nucleus (nucleoplasm and speckle), Chromosome. Shuttles between nucleus and cytoplasm (PubMed:19592491, 21157427, 21056976). KAT5/TIP60 inhibits nuclear translocation (PubMed:21157427). Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation (PubMed:19592491). Preferentially localizes across entire gene coding region (PubMed:28076779). During transcription, accumulates at chromatin loci with unscheduled R-loops and colocalizes with Ser-5-phosphorylated POLR2A/RNA polymerase II and helicase DDX23 (PubMed:28076779). |
| Species Reactivity | Human; Mouse |
Background
- Catalytic activity: ATP + a protein → ADP + a phosphoprotein
- Cofactor: Magnesium
- Enzyme regulation: Activated by phosphorylation on Ser-52 and Ser-588
- Function: Phosphorylates RS domain-containing proteins (e.g., SFRS1, SFRS2) on serine residues. Plays a role in spliceosome assembly and trafficking of splicing factors. Mediates HBV core protein phosphorylation, necessary for pregenomic RNA encapsidation into viral capsids.
- Sequence caution: The cDNA appears to contain a duplicated region.
- Similarity: Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family; contains 1 protein kinase domain.
- Tissue specificity: Highly expressed in brain, moderately in heart and skeletal muscle, and low levels in lung, liver, and kidney.
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