ELK Biotechnology ROBO1 rabbit pAb

ELK Biotechnology ROBO1 rabbit pAb

제품 정보

세포 내 위치 (Cellular Localization)

Cell membrane; Single-pass type I membrane protein.
Cell projection, axon.
Endoplasmic reticulum–Golgi intermediate compartment membrane; Single-pass membrane protein.
Detected at growth cones in thalamus neurons.
PRRG4 prevents cell surface location and both colocalize in the endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity).

배경 (Background)

Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline.
The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration.
This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain.
A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. (Provided by RefSeq, Mar 2009)