ELK Biotechnology RAB13 rabbit pAb

ELK Biotechnology RAB13 rabbit pAb

제품 개요

RAB13 rabbit pAb는 Rab 단백질 패밀리에 속하는 RAB13 단백질을 인식하는 토끼 폴리클로날 항체입니다. 이 항체는 세포막, 골지체, 재활용 엔도솜 등 다양한 세포소기관에서의 RAB13 단백질의 위치와 기능 연구에 적합합니다.

제품 정보

세포 내 위치

Cell membrane; Lipid-anchor; Cytoplasmic side.
Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side.
Cell junction, tight junction.
Golgi apparatus, trans-Golgi network membrane.
Recycling endosome membrane.
Cell projection, lamellipodium.
Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (PubMed:8294494).
Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity).

Background

This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration, and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]