Thermo Fisher Scientific PIMT Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human PIMT. Recombinant protein control fragment (Product #RP-105815). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PIMT,uniProtId:Q96RS0-1,ncbiNodeId:9606,antigenRange:217-303,antigenLength:853,antigenImageFileName:PA5-65051_PIMT_Q96RS0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65051_PIMT_Q96RS0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2664481

Product Specific Information

Immunogen sequence: KHPGQALSSEP WNFPDTKEEW EQHYSQLYWY YLEQFQYWEA QGWTFDASQS CDTDTYTSKT EADDKNDEKC MKVDLVSFPS SPIMVD

Highest antigen sequence identity to the following orthologs - mouse 72%, rat 68%.

Target Information

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.