Thermo Fisher Scientific Phospho-RAD17 (Ser645) Polyclonal Antibody
인산화 RAD17(Ser645)을 특이적으로 인식하는 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간 단백질에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 용액 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Rad17 (phospho Ser645). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.44 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7), with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736416 |
Product Specific Information
- Positive Control: HeLa
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Rad17 is essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. It has weak ATPase activity required for chromatin binding and participates in recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, as well as CHEK1 activation. Rad17 may also serve as a sensor of DNA replication progression and be involved in homologous recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(PA5-78145_RAD17_O75943-1_Rabbit.svg 및 PA5-78145_RAD17_O75943-1_Rabbit_PDP.jpeg 이미지 포함)
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