Thermo Fisher Scientific Phospho-CDC37 (Ser13) Monoclonal Antibody (8A1)
Phospho-CDC37 (Ser13) 단백질을 인식하는 Rabbit monoclonal antibody로, Western blot에 최적화됨. 세포 주기 조절 및 HSP90 관련 신호전달 연구에 활용 가능. 고순도, 1 mg/mL 농도의 액상 형태로 제공되며 -20°C 보관.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8A1 |
| Immunogen | Synthetic peptide derived from human CDC37 (S13), around 1–50aa (phospho S13) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
Target Information
In S. cerevisiae, Cdc37 is an important regulator of the cell division cycle through its action on cyclin-dependent kinases (CDKs). It is also associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase.
HSP90 has been shown to associate with many of the same cellular targets as Cdc37. Cdc37 (also known as p50) forms complexes with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf, and pp60v-src. More recently, Cdc37 has been identified as a chaperone functioning independently and in concert with HSP90, and is necessary for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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