Thermo Fisher Scientific CD3e Monoclonal Antibody (UCHT1), Qdot 605

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent
• Publications: View 11 publications

In vitro Assay (IV)

• Tested Dilution: -
• Publications: View 1 publication

Miscellaneous PubMed (Misc)

• Tested Dilution: -
• Publications: View 3 publications

Product Specifications

Additional Formats Available

• Alexa Fluor 405
• Alexa Fluor 647
• Alexa Fluor 700
• APC
• FITC
• Pacific Blue
• Pacific Orange
• PE
• Request custom conjugation

Target Information

The CD3 subunit complex is crucial for transducing antigen-recognition signals into the cytoplasm of T cells and regulating TCR complex expression. CD3 subunits (gamma, delta, epsilon, zeta) are members of the immunoglobulin superfamily encoded on chromosome 11. These subunits have long cytoplasmic tails that interact with signal transduction molecules via a double tyrosine-based motif. CD3 plays roles in TCR-induced growth arrest, cell survival, and proliferation. It is expressed on most peripheral blood lymphocytes and thymocytes but not on B or NK cells. Defects in CD3 genes are linked to CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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