Thermo Fisher Scientific INTS3 Polyclonal Antibody
Rabbit polyclonal antibody against Human INTS3, validated for IHC(P) and ICC/IF applications. Recognizes recombinant human INTS3 protein with high species homology. Suitable for research in RNA processing and DNA damage response. Supplied as liquid, un...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human INTS3. Recombinant protein control fragment (Product #RP-107993) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663643 |
Product Specific Information
Immunogen sequence:
LEHLDNLRLNL TNTKQNFFSQ TPILQALQHV QASCDEAHKM KFSDLFSLAE EYEDSSTKPP KSRRKAALSS PRSRKNATQP
- Highest antigen sequence identity to orthologs: mouse 99%, rat 98%.
Target Information
Component of the Integrator complex involved in the transcription and 3′-box-dependent processing of small nuclear RNAs (U1 and U2).
Associated with the C-terminal domain of RNA polymerase II largest subunit (POLR2A) and recruited to U1 and U2 snRNA genes.
Function:
INTS3 is a component of the SOSS complex, which acts downstream of the MRN complex to promote DNA repair and G2/M checkpoint activation. It associates with single-stranded DNA at damage sites, influencing cell-cycle checkpoint activation, recombinational repair, and genomic stability. Required for efficient homologous recombination-dependent repair of DSBs and ATM-dependent signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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