Thermo Fisher Scientific Human RPAIN Synthetic Peptide

Thermo Fisher Scientific Human RPAIN Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the carboxy terminus of human RPA interacting protein.
PEP-0446 can be used as a blocking peptide with polyclonal antibody PA5-20326.

Target Information

Replication protein A (RPA) is a single-stranded-DNA binding protein involved in numerous eukaryotic DNA processes including replication, repair, and recombination.
RPA interacting protein (RPA IP) acts as an adapter protein involved in RPA nuclear import, distinct from typical importin-mediated nuclear transport.
Multiple isoforms of RPA IP exist:

• The longest isoform localizes to the cytoplasm.
• Isoform 2 is sumoylated and located in the PML nuclear body within the nucleus.
  It has been suggested that this isoform mediates localization of the RPA complex into the PML nuclear body, participating in RPA function in DNA metabolism.

Usage Notes

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.