Thermo Fisher Scientific Ataxin 1 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:1,000

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.

Target Information

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. Clinically, ADCA is divided into three groups: ADCA types I–III.
ADCA I is genetically heterogeneous, with five genetic loci (SCA1, 2, 3, 4, and 6) mapped to different chromosomes.
ADCA II, associated with retinal degeneration (SCA7), and ADCA III, often referred to as the "pure" cerebellar syndrome (SCA5), are likely homogeneous disorders.

Several SCA genes contain CAG repeat expansions in their coding regions, leading to elongated polyglutamine tracts in the corresponding proteins. The expanded repeats are variable and unstable, often increasing in size across generations.
This locus is mapped to chromosome 6, with diseased alleles containing 41–81 CAG repeats (normal: 6–39), associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.