Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), PE, eBioscience
인간 CD11b를 인식하는 ICRF44 클론 단일클론 항체로, PE 형광표지되어 유세포분석(Flow Cytometry)에 최적화됨. 단핵구, 과립구, NK세포 등에서 CD11b 발현 분석에 사용. 4°C 암소 보관, 동결 금지.
- 카탈로그번호
- 12-0118-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), PE, eBioscience
Thermo Fisher Scientific CD11b Monoclonal Antibody (ICRF44), PE, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.5 µg)/test
Publications: View 64 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rhesus monkey, Baboon, Chimpanzee, Cynomolgus monkey |
| Published Species | Baboon, Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICRF44 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2043800 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 395 / 496 / 563 / 615 / 661 / 737 / 805
- Brilliant Violet 421 / 480 / 605 / 650 / 711 / 786
- eFluor 506
- FITC
- NovaFluor Blue, Red, Violet, Yellow Series
- PE-Cyanine5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436 / 600 / 645 / 702 / 780
- Request custom conjugation available
Product Specific Information
The ICRF44 monoclonal antibody reacts with human CD11b, a 165 kDa adhesion molecule. CD11b, associated with integrin beta2 (CD18), is expressed on the surface of monocytes, granulocytes, activated lymphocytes, and a subset of NK cells. CD11b serves as a receptor for intercellular adhesion molecules such as CD54, CD102, CD50, and iC3b, crucial in cell-cell and cell-matrix interactions.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and validated on normal human peripheral blood cells. Recommended use is 5 µL (0.5 µg) per test (approximately 10⁵–10⁸ cells/test).
Excitation: 488–561 nm; Emission: 578 nm; Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD11b (integrin alpha-M, ITGAM) forms a heterodimer with CD18 known as integrin αMβ2 (Mac-1, CR3). It is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, NK cells, dendritic cells, and microglia. CD11b/CD18 functions as a receptor for ICAM-1, ICAM-2, ICAM-4, CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X. These interactions are essential for immune cell adhesion and migration.
Expression levels vary by tissue and maturation stage, with higher expression in peritoneal macrophages than splenic macrophages. CD11b dysfunction is associated with autoimmune diseases such as systemic lupus erythematosus and ITGAM-related susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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