Thermo Fisher Scientific CD59 Monoclonal Antibody (MEM-43), APC
인간 CD59 단백질을 인식하는 Mouse IgG2a 단클론 항체로, APC 형광 표지되어 Flow Cytometry에 적합. CD59의 명확한 에피토프(W40, R53)에 결합하며 차단 활성을 가짐. 651/660 nm 형광 특성, 액상 형태로 4°C 암소 보관.
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Applications
- Flow Cytometry (Flow): 10 µL / 1×10⁶ cells
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-43 |
| Immunogen | Thymocytes and T lymphocytes |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2534485 |
Additional Formats
- Unconjugated
- Alexa Fluor 647
- Biotin
- FITC
- PE
- Request custom conjugation
Product Specific Information
This antibody reacts with a well-defined epitope (W40, R-53) on CD59 (Protectin), an 18–20 kDa GPI-anchored glycoprotein expressed on all hematopoietic cells and widely present in tissues.
It does not compete with MEM-43/5 and exhibits blocking activity.
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored inhibitor of the membrane attack complex (MAC).
It prevents complement-mediated cell lysis by binding C8 and/or C9, inhibiting pore formation.
CD59 also interacts with C5b-8 complex, serves as a low-affinity ligand for CD2, and participates in T cell costimulation and signal transduction.
Mutations in CD59 cause CD59 deficiency, leading to hemolytic anemia, thrombosis, and cerebral infarction.
Multiple alternatively spliced transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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