Thermo Fisher Scientific DIS3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human DIS3 protein for WB and IP applications. Recognizes region 858–908 of DIS3 involved in RNA processing and degradation. Supplied as unconjugated liquid form (1 mg/mL), stored at 4°C, shipped on wet ice.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 858 and 908 of human DIS3 mitotic control homolog |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
The exosome is involved in a multitude of cellular RNA processing and degradation events.
DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species.
DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain.
It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression.
Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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