Thermo Fisher Scientific CD20 (MS4A1) Monoclonal Antibody (OTI11F7), TrueMAB
CD20 단백질을 인식하는 Mouse IgG1 단일클론 항체로, 인간 시료에 반응합니다. ELISA 및 Luminex 분석에 사용 가능하며, 고순도의 액상 형태로 제공됩니다. PBS 완충액 내 보존제로 sodium azide를 포함하며, -20°C에서 보관합니다.
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Applications
ELISA (ELISA)
- Tested Dilution: 1:100 - 1:1,000
Luminex (LUM)
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11F7 |
| Immunogen | Full length human recombinant protein of human MS4A1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with <5% trehalose |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Additional Formats
Target Information
CD20 is a non-glycosylated surface phosphoprotein with a molecular weight of 33–37 kDa depending on phosphorylation. It is expressed on mature and most malignant B cells, a subset of T lymphocytes, and follicular dendritic cells. CD20 expression coincides with surface IgM expression and regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation.
CD20 is associated with lipid rafts, and its interaction depends on extracellular signals, conformational changes, and BCR aggregation. Upon receptor ligation, CD20 and BCR colocalize transiently before BCR endocytosis, while CD20 remains at the surface. Due to its stable surface expression, CD20 serves as a key therapeutic target for B-cell depletion in malignancies. Dysfunctions in CD20 (MS4A1) are linked to common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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