Thermo Fisher Scientific tPA Recombinant Rabbit Monoclonal Antibody (32B1)
Recombinant rabbit monoclonal antibody (clone 32B1) specific for human tPA, suitable for ELISA and flow cytometry. High purity via affinity chromatography, supplied as liquid at 3 mg/mL in PBS with glycerol. For research use only.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1:50–1:200
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 32B1 |
| Immunogen | A synthesized peptide derived from Human PLAT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092598 |
Target Information
tPA converts the abundant but inactive zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling, degradation, cell migration, and other physiological and pathological events.
tPA is a heterodimer of chain A and chain B held by a disulfide bond and binds to fibrin with high affinity, increasing catalytic efficiency by 100–1000-fold. Binding to heparin, laminin, and fibronectin enhances plasminogen activation.
It also interacts with mannose receptor and LRP1, which are involved in tPA clearance, as well as annexin II and cytokeratin 8. Binding to vascular smooth muscle cells reduces inhibition by PAI-1 and stimulates plasminogen activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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