Thermo Fisher Scientific CD81 Polyclonal Antibody
CD81 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 액상 형태로 1 mg/mL 농도, PBS와 글리세롤 버퍼에 보관. 세포 표면 단백질 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CD81 (Accession P60033), corresponding to amino acid residues G112–L162 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899353 |
Product Specific Information
This antibody detects endogenous levels of total CD81.
Target Information
CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family expressed on most nucleated cells, particularly germinal center B cells. It forms complexes with other tetraspanins, integrins, coreceptors, and MHC molecules, influencing adhesion, activation, proliferation, and differentiation of immune cells.
In muscle tissue, CD81 promotes cell fusion and myotube maintenance. It also serves as a receptor for the hepatitis C virus.
Like other tetraspanins (CD9, CD37, CD53, CD63, CD82), CD81 is a cell-surface glycoprotein with four hydrophobic domains, mediating signal transduction involved in cell development and motility. CD81 associates with CD19, CD21, Leu 13, and integrins, and antibodies to CD81 can have anti-proliferative effects on lymphoid cell lines. CD81 is localized in a tumor-suppressor gene region and is considered a candidate gene for malignancies.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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