Thermo Fisher Scientific beta-2 Microglobulin Recombinant Rabbit Monoclonal Antibody (201)
인간 beta-2 microglobulin을 인식하는 재조합 토끼 단일클론 항체입니다. Western blot과 Immunoprecipitation에 적합하며, 고순도 Protein A 정제 제품입니다. HEK293 세포에서 발현되었으며, PBS 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific beta-2 Microglobulin Recombinant Rabbit Monoclonal Antibody (Clone 201)
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- Immunoprecipitation (IP): 0.2–1 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 201 |
| Immunogen | Recombinant Human B2M / beta-2 microglobulin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898798 |
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms part of the major histocompatibility complex (MHC) class I. It is associated with HLA Class I antigens expressed on various cell types such as lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial, and epithelial cells, but absent on erythrocytes.
B2M is also found freely in plasma and exhibits sequence homology to immunoglobulin constant regions with a predominantly beta-pleated sheet structure. The protein is involved in antigen processing and presentation, TCR signaling, and downstream signaling in naive CD8+ cells.
The B2M gene, located on chromosome 15, encodes this protein; mutations can lead to hypercatabolic hypoproteinemia. Beta-2-microglobulin levels serve as a marker for renal function and as a prognostic indicator in HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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