Thermo Fisher Scientific ATP2B1 Monoclonal Antibody (3E2)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.3 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKT

Target Information

The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to other ATPases including the SERCA ATPase and the sodium/potassium pump.
There are four different genes encoding PMCA ATPase, and studies have revealed 20 isoforms generated by alternate splicing.
mRNA distribution studies show that gene products 1 and 4 are expressed in most tissues, while products 2 and 3 are tissue-specific.
In the pancreas, beta cells express only the 4b isoform, while alpha and gamma cells express both 4a and 4b isoforms.
Different splice variants exhibit varying affinities for calcium and calmodulin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.