Thermo Fisher Scientific ATP2B1 Monoclonal Antibody (3E2)
ATP2B1 단백질을 인식하는 마우스 단일클론 항체로, Western blot 및 ELISA에 적합. 인간 시료 반응성. PBS 용액 형태로 제공되며, 보존제 무첨가. 연구용으로만 사용 가능.
- 카탈로그번호
- H00000490-M01
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3E2 |
| Immunogen | ATP2B1 (NP_001673, 1–97 a.a.) 부분 재조합 단백질 (GST tag 포함, GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKT
Target Information
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to other ATPases including the SERCA ATPase and the sodium/potassium pump.
There are four different genes encoding PMCA ATPase, and studies have revealed 20 isoforms generated by alternate splicing.
mRNA distribution studies show that gene products 1 and 4 are expressed in most tissues, while products 2 and 3 are tissue-specific.
In the pancreas, beta cells express only the 4b isoform, while alpha and gamma cells express both 4a and 4b isoforms.
Different splice variants exhibit varying affinities for calcium and calmodulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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