Thermo Fisher Scientific p53 VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1165)

Applications

ELISA (ELISA)

• Tested Dilution: Assay-dependent

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Compatible with Direct ELISA

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. p53 up-regulation activates transcription of genes such as p21waf1, leading to G1 or G2/M arrest.
Its structure includes:

• N-terminal transactivation domain
• Central DNA-binding domain
• Oligomerisation domain
• C-terminal regulatory domain

Phosphorylation at Ser15 is critical for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 functions as an anticancer agent by preventing proliferation of damaged cells and is implicated in aging, oxidative stress, and cognitive processes such as long-term potentiation.
Mutations in p53 disrupt DNA binding and tumor suppressor activity, contributing to malignancy. Alterations in the TP53 gene occur as somatic or germline mutations, including in Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.