Thermo Fisher Scientific TNF alpha VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1201)
인간 TNF alpha를 인식하는 알파카 유래 재조합 단일클론 항체로, ELISA, WB, ICC/IF, Flow Cytometry, SPR 등 다양한 분석에 사용 가능. CHO 세포 발현, 금속 킬레이트 크로마토그래피 정제, 1.8 mg/mL 농도, 연구용 전용 제품.
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Applications
- Western Blot (WB): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- Flow Cytometry (Flow): Assay-dependent
- ELISA: Assay-dependent
- Surface Plasmon Resonance (SPR): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1201 |
| Immunogen | Recombinant Human TNFα / TNF-alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.8 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
Compatible with Direct ELISA.
Target Information
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is mainly secreted by macrophages and binds to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha regulates immune cell activity, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.
TNF alpha exists as multimers of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice suggest its neuroprotective function and tumor necrosis activity when injected into tumor-bearing mice. It plays a key role in immune responses to bacterial, viral, parasitic, and fungal infections and contributes to tumor necrosis of specific cells. TNF alpha acts synergistically with interferon-gamma in cytotoxicity and has been implicated in autoimmune diseases, insulin resistance, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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