Thermo Fisher Scientific Protein Kinase C iota/lambda/PRKCI Monoclonal Antibody (PRKCI/4912)
PRKCI/4912 단일클론 항체로 인간 PRKCI 단백질(aa100-300)을 인식합니다. IHC(P), IHC(PFA), Peptide Array 등 다양한 응용에 적합합니다. Protein A/G 정제, 1 mg/mL 농도의 액상 형태로 제공되며, PBS(pH 7.4)에 보존제 없이 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PRKCI/4912 |
| Immunogen | Recombinant fragment (around aa100–300) of human PRKCI protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The PKC family of serine/threonine kinases, including PRKCI (PKC iota), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. The PKC family comprises at least eight members that are differentially expressed and involved in various cellular processes.
This protein kinase is calcium-independent and phospholipid-dependent, not activated by phorbol esters or diacylglycerol. It can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where it phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. It is necessary for BCL-ABL-mediated resistance to drug-induced apoptosis, protecting leukemia cells against drug-induced apoptosis. A single exon pseudogene is mapped on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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